Leaky Gut Syndrome Vasculitis

How to Heal Leaky Gut Syndrome

Okay, well, I want to welcome everyone. Thisis Nik Hedberg, and tonight we're talking about how to heal leaky gut syndrome. So,let's get this started. I really enjoy doing these webinars, tryingto get some good information out there to everyone. And leaky gut, it's a big issue.Its main connections are going to be with autoimmune diseases and a variety of chronicconditions, which we'll talk about. I'm just going to cover what it is, what causes leakygut, and then some of the things that you can do about it, and then how we manage itin the practice if it's there. The medical term for leaky gut is gastrointestinalhyperpermeability. It is recognized in conventional

medicine, but it's really not going to berecognized by your average . They kind of look down on it or laugh at it, so to speak,but it is definitely something very real. So, let's go ahead and jump right in. Gettingto the symptoms, conditions associated, conditions connected with leaky gut syndrome, and asI mentioned, autoimmune diseases are a big one, like Hashimoto's thyroiditis, Graves'disease, lupus, Sjögren's, alopecia, rheumatoid arthritis, et cetera. A lot of the symptoms you'll see are fatigue,brain fog. Brain fog is basically inflammation of the brain. Because we don't have pain receptorsin the brain, that's basically how the body

tells us that the brain is inflamed when there'sfogginess. And there's a really strong connection there between the gut and the brain just in general. Weight gain, depression and anxiety. There'sa lot of literature out there connecting chronic inflammation and inflammation in the gut andpsychological issues like depression and anxiety. Different digestive problems, like IrritableBowel Syndrome, Crohn's disease, all sorts of colitis, and then just general symptomslike gas, bloating, cramping, things like that. Food allergies, of course. Arthritis and jointpain, migraine headaches, adrenal gland imbalances,

and then what we call adrenal fatigue, andthen of course asthma and allergies. The gut barrier is called a mucosal barrier,and if there's dysfunction there, there's going to be dysfunction in the other mucosalbarriers like the lungs, for example. So, what is leaky guté What you see here onthe left is what we will call a healthy gut lining. These are what we call villi, they'relike fingers, and that's where all of the absorption occurs in between these gaps. Thisis also where the immune system is. So the gut barrier protects you from a lot of differentthings. It protects you from infections like viruses, bacteria, fungi, parasites, it protectsyou from absorbing undigested protein, and

so it's this mucosal barrier that's very protective. Now, leaky gut is when that barrier becomesbroken down, and you can see it's all flat here, all of the villi have been compromised.And so when you have leaky gut, you can also have malabsorption. That might be kind ofdifficult to understand for some people, but the intestinal barrier is selective, and whenthe immune system becomes compromised, then it can no longer protect you from the varietyof things that we just talked about. Malabsorption means that the absorptive capacityof the gut barrier is not what it used to be, so people will start to develop nutrientdeficiencies and they won't be able to absorb

protein, carbohydrates and fat. So this isa visual of what we call leaky gut. Now, these are some of the main causes. Whatyou see here in the pink is a diagram of the intestinal barrier. I want to give creditto Aristo Vojdani, he is an immunologist for this slide, and Vojdani has spokenextensively on leaky gut. So these are some of the main things thatwe see up here. Dietary proteins and peptides, so that's going to be like gluten, dairy andother allergies; other foods that are highly allergenic; antibodies, and that's if there'ssome kind of infection in the intestine; drugs and xenobiotics, so environmental chemicals,environmental toxins; prescription medications,

The Traditional Chinese Medicine Diet

Hey guys, Axe here, of naturalmedicine and founder of DrAxe . In this tutorial I'm going to talk to you about TCM Diet,also known as the Traditional Chinese Medicine Diet, and ways that Chinese medicine can helpyou transform your health. Within Chinese medicine there's somethingcalled The Five Elements. The Five Elements, this also stems from something called FiveElements Acupuncture, but I'll tell you, by learning these principles it's going to helpyou really know your own body. I think this is what everybody wants. Everybody wants toknow a custom and personalized plan for them, and so I'm going to teach you in this tutorialwhat type you might be so you know the exact

steps you need to take to heal your body completelyusing TCM, that's Traditional Chinese Medicine. Traditional Chinese Medicine has been usedover 4000 years and I believe today it's the most accurate way of diagnosing and treatingillness, much more accurate than our conventional medical Western system today. There are Five Elements of Chinese Medicinethat relate to the earth, and the way our organ system works, our five organ systems.Let's talk about the first element. That's the Wood Element in Chinese Medicine. Thathas to do with springtime, also that's related to green foods. If you are struggling witha liver issue or a gallbladder issue to where

you don't digest fats properly, or you haveany type of liver condition, elevated liver enzymes, or you've ever been exposed to toxins,then that means you want to follow the Wood Element Diet. Now, also people can be Wood Elements, andthat's me, for instance. Wood Element people are typically very wiry, they're typically. . . you can see their veins, they typically would look like sometimes rock climbersish,but again they're a little bit more lean and wiry. When you hear the Wood Element, thinktree roots. So think roots and how they're built. That's a Wood Element and those peopletend to be more susceptible to liver and gallbladder

issues and not digesting fats properly. Andthe emotion that they experience is frustration and sometimes anger. So think angry drunk.If you have an angry drunk what does that affecté It affects their liver and vice versa.Somebody has liver problems they can burst out in anger. So again, that's the Wood Elementin Chinese Medicine. If you are having liver issues or gallbladderissues at all, gallstones, gallbladder removed, any sort of anger frustration issues, youwant to start nourishing those organs. And this is the big difference in Chinese Medicine.In Western Medicine today we try and treat a disease, treat an illness; in Chinese Medicinethey look to nourish an organ to help the

body heal. And the foods that are most nourishingand healing to the liver and gallbladder are going to be foods that are sour. So thinksauerkraut, also things like a green apple, also foods that are slightly bitter. Foodsthat are mostly sour and slightly bitter are the most nourishing, and foods that are verygreen. Wood Element, think trees, think green, think grass, so vegetables like fresh saladand spinach, veggies juices, herbs like milk thistle and dandelion. Also bluporum is anotherone in Chinese Medicine, and then green apples, but think green foods, fresh foods, livingfoods, those are going to be the best for healing the liver and the gallbladder in foodsthat are sour.

The next element in Chinese Medicine is goingto be your Earth Element, and the Earth Element is going to be for people that tend to bea little bit more round. Sometimes people that tend to be a little more jolly. Sometimesthey'll get some redness in their cheeks. The Earth Element tends to be people thatemotionally struggle with worry, and it also from a seasonal standpoint has to do withthe fall harvest. People that are the Earth Element tend to struggle with candida. Soif you're a person that you know you're a chronic worrier or if you've ever struggledwith candida, the Chinese Medicine or TCM Diet can help you. Specifically, you wantto do foods that nourish the spleen and so

Identifying Dysregulated Genes in Autoimmune Disease Chris Cotsapas

Chris Cotsapas:I'd like to thank the organizers for the opportunity to come talk to you guys aboutwhat we've been thinking about in my lab. So, what I'm going to talk about primarilyis stuff that's going on. So, all of this is unpublished. Feel free to think about it,share it, whatever. But it's very much work in progress. Some of it is hot off the press.So, do take it with a pinch of salt. So, what we think about a lot is autoimmune diseasesin my lab. And we kind of want to think about which genes go wrong in disease, and we thinkabout these regulatory genes. But actually what we're interested in are the causalgenes. And my pointer doesn't work. I can

use this pointer. It's all coming up Christoday. So, we're thinking more about causalitythan anything else. So, when we say dysregulation, we're interested in pathogenesis, rightéThat's ultimately what we're after. And so, just a 30,000 foot view of the immunesystem. If you remember, you start with a stem cell. You have two major lineages inthe immune system, that the lymphoid and the myeloid lineages. So, things like macrophagesare all the way down here. And your T cells and B cells are all the way down here. Ifyou think of you think of them as adaptive versus innate. And what happens is every nowand then, this goes wrong. So, the immune

system's primary function is to protectthe body from things that are foreign. And so it's got this amazing capacity to tellthe difference between your cells and the rest of world. And it's really good at this,but occasionally it screws up. And it kind of what happens is that it starts attackingcertain tissues. So, if it doesn't like myelin, you get multiplesclerosis. The immune systems manage to go into the brain and attack the myelin sheathspelled phonetically very specifically around neurons, chew it up, and you get lesions intoyour brain. You can get things like skin attacks which give you Sjogren's syndrome, scleroderma,you can get type 1 diabetes, which we now

know is an immune disease. If it doesn'tlike aspects of the GI tract, you wind up with Crohn's disease, ulcerative colitis,or celiac disease if it doesn't like the epithelia joint; specific joint dislikes,should we say, give you rheumatoid arthritis or ankylosing spondylitis. And if it justdoesn't like DNA, if it doesn't like nucleic acid, it attacks everything, then you windup something called lupus, righté What's really interesting is that these are very,very, specific dislikes. So, MS is not rheumatoid arthritis. It's a very specific attack againstmyelin. It's not a specific attack against anything else.

And what we really want to understand is whatthese diseases are. So, something's going wrong with the immune system. We don't reallyunderstand what it is. What we do know is that all of these diseases are common. They'recomplex genetic diseases. There's a large portion of heritability. They track in families.But they're not Mendelian. It's not one catastrophic mutation, righté And, of course,as GWAS came along, I'm going to talk about multiple sclerosis, which is something thatI work on. But you can take this as read for any immune disease. As GWAS came along, wehadn't really gotten a lot of traction on the genetics of these diseases. And then,sort of we barely managed to identify two

loci in the genome in one of the first GWASstudies. Then a little while later, we managed to get another one. A metaanalysis of thesetwo sets of studies from international consortia kind of gave six new hits, and we're startingto climb this power curve of discovery. Then a further metaanalysis with more markersand a few more samples gave us an additional three new hits. Even more samples gave usanother 25 new hits. The immunochip gave us 47. That took us up to 100. And our currentstudies, which are about 16,000 cases, 26,000 controls and replication in another 36,000samples, we've got another 100 odd new hits. So, we're standing at around 200 loci rightnow in GWAS, righté That explains including

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